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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 59 40.51 72.64 51,548,116
Mutual Fund 19 3.30 4.65 3,298,411
Insider 6 0.79 1.00 711,761

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 12 0.29 0.55 389,940
Sellers 16 -1.04 1.95 -1,381,886
Net -- -0.75 1.40 -991,946

Concentration

Value ($MM) % O/S Shares
Total Inst. 40.51 72.64 51,548,116
Top 10 Inst. 35.03 62.84 44,598,317
Top 20 Inst. 38.68 69.78 49,520,328
Top 50 Inst. 40.51 72.63 51,542,356

Style

Holders Value ($MM) % Inst Shares Shares
Growth 4 0.39 0.75 531,403
Aggressive Growth 1 0.35 0.69 489,825
Core Growth 2 -- -- 556
Growth 1 0.04 0.06 41,022
Income 2 0.02 0.04 27,642
Income Value 1 0.02 0.04 26,226
Yield 1 -- -- 1,416
Index 5 1.60 3.14 2,227,246
Other 22 24.77 45.69 32,426,485
Broker Dealer 5 0.94 1.85 1,310,552
GARP 3 0.12 0.18 126,675
Hedge Fund 10 12.73 24.98 17,725,065
Sector Specific 1 0.18 0.35 250,000
VC/Private Equi 3 10.80 18.34 13,014,193
Value 5 0.29 0.56 396,268
Core Value 2 0.04 0.08 54,890
Deep Value 3 0.25 0.48 341,378

Location: Global Region

Holders % O/S Shares Share Change
North America 47 65.96 46,813,012 -656,192
Europe 2 4.93 3,500,093 --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,936,000 9.77 -- 12/31/18
Stonepine Capital Management, LLC 6,547,774 9.23 -440,082 12/31/18
venBio Select Advisor LLC 6,240,000 8.79 -1,581 12/31/18
Deerfield Management Company, L.P. 6,052,935 8.53 -- 12/31/18
Scale Management, LLC 3,852,134 5.43 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.11 -- 4/27/18
HBM Partners AG 3,500,000 4.93 -- 12/31/18
Polaris Venture Partners 3,148,355 4.44 -- 12/31/18
Palo Alto Investors LP 3,013,793 4.25 -- 12/31/18
The Vanguard Group, Inc. 1,681,488 2.37 -408,034 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 984,969 1.39 -- 2/28/19
Vanguard Extended Market Index Fund 518,727 0.73 -- 2/28/19
Bridgeway Ultra-Small Company Market Fund 360,000 0.51 -- 12/31/18
B. Riley Diversified Equity Fund 336,000 0.47 -24,000 12/31/18
Royce Value Trust 319,186 0.45 120,000 12/31/18
iShares Micro-Cap ETF 150,153 0.21 -11,060 3/31/19
iShares Core S&P Total U.S. Stock Market ETF 116,470 0.16 9,300 3/31/19
VALIC Co I Small Cap Fund 115,025 0.16 -- 1/31/19
Vanguard Institutional Total Stock Market Index Fund 114,589 0.16 -- 2/28/19
Fidelity Extended Market Index Fund 100,515 0.14 -- 2/28/19

* Insider values reflect direct beneficial ownership.

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