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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 60 44.00 74.89 52,481,277
Mutual Fund 19 3.00 4.74 3,323,309
Insider 6 0.64 1.02 711,761

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 14 0.98 1.43 999,940
Sellers 20 -6.72 7.69 -5,389,332
Net -- -5.75 6.26 -4,389,392

Concentration

Value ($MM) % O/S Shares
Total Inst. 44.00 74.89 52,481,277
Top 10 Inst. 37.17 63.64 44,598,317
Top 20 Inst. 42.03 71.60 50,174,803
Top 50 Inst. 43.99 74.88 52,473,825

Style

Holders Value ($MM) % Inst Shares Shares
Growth 4 0.39 0.76 531,403
Aggressive Growth 1 0.35 0.70 489,825
Core Growth 2 -- -- 556
Growth 1 0.04 0.06 41,022
Income 2 0.02 0.04 27,642
Income Value 1 0.02 0.04 26,226
Yield 1 -- -- 1,416
Index 5 1.60 3.18 2,227,246
Other 23 26.03 47.57 33,335,646
Broker Dealer 5 0.94 1.87 1,310,552
GARP 3 0.09 0.18 126,675
Hedge Fund 10 12.73 25.29 17,725,065
Sector Specific 1 0.18 0.36 250,000
VC/Private Equi 4 12.09 19.87 13,923,354
Value 5 0.28 0.57 396,268
Core Value 2 0.04 0.08 54,890
Deep Value 3 0.25 0.49 341,378

Location: Global Region

Holders % O/S Shares Share Change
North America 48 68.13 47,746,173 -4,240,511
Europe 2 4.99 3,500,093 250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,936,000 9.90 -- 12/31/18
Stonepine Capital Management, LLC 6,547,774 9.34 -440,082 12/31/18
venBio Select Advisor LLC 6,240,000 8.90 -1,581 12/31/18
Deerfield Management Company, L.P. 6,052,935 8.64 -- 12/31/18
Scale Management, LLC 3,852,134 5.50 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.17 -- 4/27/18
HBM Partners AG 3,500,000 4.99 250,000 12/31/17
Polaris Venture Partners 3,148,355 4.49 -- 12/31/18
Palo Alto Investors LP 3,013,793 4.30 -- 12/31/18
The Vanguard Group, Inc. 1,681,488 2.40 -408,034 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 984,969 1.41 -- 1/31/19
Vanguard Extended Market Index Fund 518,727 0.74 -- 1/31/19
Bridgeway Ultra-Small Company Market Fund 360,000 0.51 -- 12/31/18
B. Riley Diversified Equity Fund 360,000 0.51 360,000 9/30/18
Royce Value Trust 319,186 0.46 120,000 12/31/18
iShares Micro-Cap ETF 157,263 0.22 -3,950 1/31/19
VALIC Co I Small Cap Fund 115,025 0.16 -- 12/31/18
Vanguard Institutional Total Stock Market Index Fund 114,589 0.16 -- 1/31/19
iShares Core S&P Total U.S. Stock Market ETF 108,370 0.15 1,200 1/31/19
Fidelity Extended Market Index Fund 100,515 0.14 -- 12/31/18

* Insider values reflect direct beneficial ownership.

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