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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 50 40.57 65.47 46,484,393
Mutual Fund 23 2.69 4.80 3,407,810
Insider 10 1.33 1.93 1,367,997

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 19 1.69 2.61 1,855,099
Sellers 22 -2.01 3.07 -2,178,296
Net -0.32 0.46 -323,197

Concentration

Value ($MM) % O/S Shares
Total Inst. 41.90 67.40 47,852,390
Top 10 Inst. 35.40 57.37 40,730,368
Top 20 Inst. 40.23 64.84 46,035,510
Top 50 Inst. 41.90 67.39 47,847,166

Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.63 0.99 701,362
Aggressive Growth 1 0.52 0.83 589,825
Core Growth 3 0.06 0.10 70,515
Growth 1 0.04 0.06 41,022
Income 2 0.02 0.04 27,010
Income Value 1 0.02 0.04 25,594
Yield 1 -- -- 1,416
Index 5 1.92 3.03 2,151,856
Other 21 28.79 45.96 32,629,762
Broker Dealer 3 1.18 1.86 1,324,029
GARP 4 0.11 0.18 127,182
Hedge Fund 11 16.17 25.58 18,164,358
Specialty -- --
VC Private Equity 3 11.33 18.33 13,014,193
Value 5 0.55 0.88 622,047
Core Value 2 0.04 0.06 43,935
Deep Value 3 0.51 0.81 578,112

Location: Global Region

Holders % O/S Shares Share Value
North America 58 62.47 44,352,297 39,386,656
Europe 2 4.93 3,500,093 2,513,433

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Stonepine Capital Management, LLC 6,439,498 9.07 -44,112 6/30/19
Avoro Capital Advisors LLC 6,240,000 8.79 -- 6/30/19
Deerfield Management Company, L.P. 6,052,935 8.53 -- 6/30/19
Armistice Capital LLC 5,836,000 8.22 -1,100,000 6/30/19
Domain Associates, L.L.C. 3,625,838 5.11 -- 4/22/19
HBM Partners AG 3,500,000 4.93 -- 12/31/18
Polaris Venture Partners 3,148,355 4.43 3,148,355 12/31/18
Palo Alto Investors LP 3,013,793 4.24 -- 6/30/19
The Vanguard Group, Inc. 1,710,492 2.41 1,300 6/30/19
Morgan Stanley & Co. LLC 1,163,457 1.64 -154 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 937,766 1.32 -48,959 7/31/19
Royce Value Trust 571,275 0.80 252,089 3/31/19
Vanguard Extended Market Index Fund 546,431 0.77 -- 6/30/19
Bridgeway Ultra-Small Company Market Fund 460,000 0.65 -- 6/30/19
iShares Core S&P Total U.S. Stock Market ETF 127,950 0.18 220 7/31/19
VALIC Co I Small Cap Fund 115,025 0.16 -- 6/30/19
Vanguard Institutional Total Stock Market Index Fund 114,589 0.16 -- 7/31/19
Fidelity Extended Market Index Fund 100,515 0.14 -- 6/30/19
Schwab Total Stock Market Index Fund 39,406 0.06 -- 7/31/19
Vanguard Balanced Index Fund 32,384 0.05 -- 6/30/19

* Insider values reflect direct beneficial ownership.

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