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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 62 51.63 71.14 49,852,972
Mutual Fund 19 3.63 5.14 3,599,467
Insider 5 1.06 1.18 825,053

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 19 1.78 2.47 1,728,576
Sellers 20 -6.67 7.14 -5,006,494
Net -- -4.89 4.67 -3,277,918

Concentration

Value ($MM) % O/S Shares
Total Inst. 51.63 71.14 49,852,972
Top 10 Inst. 44.87 62.03 43,467,784
Top 20 Inst. 49.74 68.47 47,982,377
Top 50 Inst. 51.63 71.13 49,843,631

Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.52 0.76 531,503
Aggressive Growth 1 0.48 0.70 489,825
Core Growth 3 -- -- 656
Growth 1 0.04 0.06 41,022
Income 2 0.03 0.04 27,642
Income Value 1 0.03 0.04 26,226
Yield 1 -- -- 1,416
Index 5 2.57 3.75 2,625,240
Other 26 30.64 43.29 30,336,412
Broker Dealer 6 1.26 1.84 1,288,093
GARP 3 0.14 0.21 144,125
Hedge Fund 13 17.52 25.51 17,877,614
Sector Specific 1 0.24 0.36 250,000
VC/Private Equi 3 11.47 15.38 10,776,580
Value 6 0.27 0.39 276,403
Core Value 3 0.05 0.08 55,025
Deep Value 3 0.22 0.32 221,378

Location: Global Region

Holders % O/S Shares Share Change
North America 51 64.90 45,481,529 -3,348,189
Europe 2 4.99 3,500,093 250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Stonepine Capital Management, LLC 6,987,856 9.97 6,672 9/30/18
Armistice Capital LLC 6,936,000 9.90 -- 9/30/18
venBio Select Advisor LLC 6,241,581 8.91 -- 9/30/18
Deerfield Management Company, L.P. 6,052,935 8.64 -- 9/30/18
Scale Management, LLC 3,852,134 5.50 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.17 -- 4/27/18
HBM Partners AG 3,500,000 4.99 250,000 12/31/17
Palo Alto Investors LP 3,013,793 4.30 -- 9/30/18
The Vanguard Group, Inc. 2,089,522 2.98 7,440 9/30/18
Morgan Stanley & Co. LLC 1,168,125 1.67 36,198 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,393,003 1.99 -- 11/30/18
Vanguard Extended Market Index Fund 518,727 0.74 -- 11/30/18
Bridgeway Ultra-Small Company Market Fund 360,000 0.51 -- 9/30/18
B. Riley Diversified Equity Fund 360,000 0.51 360,000 9/30/18
Royce Value Trust 199,186 0.28 199,186 9/30/18
iShares Micro-Cap ETF 154,893 0.22 -9,480 11/30/18
VALIC Co I Small Cap Fund 115,025 0.16 -- 10/31/18
Vanguard Institutional Total Stock Market Index Fund 114,589 0.16 -- 11/30/18
iShares Core S&P Total U.S. Stock Market ETF 100,910 0.14 5,280 11/30/18
Fidelity Extended Market Index Fund 100,515 0.14 -- 10/31/18

* Insider values reflect direct beneficial ownership.

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