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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 50 51.78 71.23 50,577,038
Mutual Fund 23 3.64 5.08 3,607,278
Insider 11 1.36 1.85 1,310,144

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 21 3.41 5.98 4,248,134
Sellers 23 -0.95 1.41 -997,688
Net 2.46 4.58 3,250,446

Concentration

Value ($MM) % O/S Shares
Total Inst. 53.14 73.08 51,887,182
Top 10 Inst. 45.41 62.76 44,561,857
Top 20 Inst. 51.03 70.20 49,842,296
Top 50 Inst. 53.13 73.07 51,882,172

Style

Holders Value ($MM) % Inst Shares Shares
Growth 6 0.72 0.96 681,903
Aggressive Growth 1 0.63 0.83 589,825
Core Growth 4 0.05 0.07 51,056
Growth 1 0.04 0.06 41,022
Income 2 0.03 0.04 27,010
Income Value 1 0.03 0.04 25,594
Yield 1 -- -- 1,416
Index 5 2.42 3.22 2,283,861
Other 21 33.53 45.69 32,438,795
Broker Dealer 4 1.38 1.84 1,303,453
GARP 3 0.13 0.18 126,675
Hedge Fund 11 19.07 25.34 17,994,474
Specialty -- --
VC Private Equity 3 12.94 18.33 13,014,193
Sector Specific -- -- -- --
Value 5 0.69 0.91 648,357
Core Value 2 0.06 0.08 54,890
Deep Value 3 0.63 0.84 593,467

Location: Global Region

Holders % O/S Shares Share Value
North America 59 68.15 48,387,089 50,626,678
Europe 2 4.93 3,500,093 2,513,449

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,936,000 9.77 -- 3/31/19
Stonepine Capital Management, LLC 6,483,610 9.13 -64,164 3/31/19
Avoro Capital Advisors 6,240,000 8.79 -- 3/31/19
Deerfield Management Company, L.P. 6,052,935 8.53 -- 3/31/19
Scale Management, LLC 3,852,134 5.43 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.11 -- 4/27/18
HBM Partners AG 3,500,000 4.93 -- 12/31/18
Polaris Venture Partners 3,148,355 4.43 3,148,355 12/31/18
Palo Alto Investors LP 3,013,793 4.24 -- 3/31/19
The Vanguard Group, Inc. 1,709,192 2.41 27,704 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 985,425 1.39 -- 4/30/19
Royce Value Trust 571,275 0.80 252,089 3/31/19
Vanguard Extended Market Index Fund 546,431 0.77 -- 4/30/19
Bridgeway Ultra-Small Company Market Fund 460,000 0.65 100,000 3/31/19
B. Riley Diversified Equity Fund 286,000 0.40 -50,000 3/31/19
iShares Micro-Cap ETF 149,363 0.21 -790 4/30/19
iShares Core S&P Total U.S. Stock Market ETF 119,450 0.17 2,980 4/30/19
VALIC Co I Small Cap Fund 115,025 0.16 -- 3/31/19
Vanguard Institutional Total Stock Market Index Fund 114,589 0.16 -- 4/30/19
Fidelity Extended Market Index Fund 100,515 0.14 -- 3/31/19

* Insider values reflect direct beneficial ownership.

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