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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 67 65.44 67.89 46,945,139
Mutual Fund 20 3.68 4.23 2,923,517
Insider 6 0.82 1.01 697,473

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 22 8.66 10.21 7,061,754
Sellers 20 -7.10 7.27 -5,029,075
Net -- 1.56 2.94 2,032,679

Concentration

Value ($MM) % O/S Shares
Total Inst. 65.44 67.89 46,945,139
Top 10 Inst. 55.69 57.64 39,855,217
Top 20 Inst. 63.01 65.33 45,173,466
Top 50 Inst. 65.39 67.84 46,913,268

Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 1.36 1.45 1,002,943
Aggressive Growth 1 0.80 0.85 589,825
Core Growth 9 0.56 0.60 413,118
Income 1 0.04 0.04 26,226
Income Value 1 0.04 0.04 26,226
Index 5 3.40 3.64 2,516,948
Other 30 48.86 50.37 34,830,496
Broker Dealer 5 0.23 0.24 167,794
GARP 4 0.24 0.25 173,950
Hedge Fund 15 24.44 26.18 18,102,213
Sector Specific 1 0.34 0.36 250,000
VC/Private Equi 5 23.62 23.34 16,136,539
Value 6 0.12 0.13 89,053
Core Value 4 0.09 0.10 70,377
Deep Value 2 0.03 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 57 62.07 42,922,547 -501,037
Europe 1 4.70 3,250,000 3,250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,264,000 9.06 364,000 9/30/17
venBio Select Advisor LLC 6,241,581 9.03 350,000 9/30/17
Deerfield Management Company, L.P. 6,052,935 8.75 1,283,384 9/30/17
Scale Management, LLC 3,977,391 5.75 -- 4/25/17
Domain Associates, L.L.C. 3,625,838 5.24 -- 4/25/17
HBM Partners AG 3,250,000 4.70 3,250,000 12/31/16
Polaris Venture Partners 3,148,355 4.55 -- 9/30/16
Palo Alto Investors, LLC 3,013,793 4.36 -- 9/30/17
Sofinnova Ventures, Inc. 2,211,604 3.20 -75,614 5/10/16
The Vanguard Group, Inc. 2,069,720 2.99 468,458 9/30/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,374,781 1.99 -- 10/31/17
Vanguard Extended Market Index Fund 487,165 0.70 -- 10/31/17
Bridgeway Ultra-Small Company Market Fund 260,000 0.38 -234,444 6/30/17
Vanguard Institutional Total Stock Market Index Fund 132,811 0.19 -- 10/31/17
VALIC Co I Small Cap Fund 115,025 0.17 -- 9/30/17
Fidelity Extended Market Index Fund 102,415 0.15 -- 10/31/17
iShares Micro-Cap ETF 101,883 0.15 3,815 11/30/17
iShares Core S&P Total U.S. Stock Market ETF 83,930 0.12 6,640 11/30/17
Worldwide Healthcare Trust PLC 62,500 0.09 -- 10/31/17
TFS Market Neutral Fund 51,207 0.07 35,602 7/31/17

* Insider values reflect direct beneficial ownership.

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