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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 61 51.16 68.00 47,627,662
Mutual Fund 17 2.63 4.47 3,129,294
Insider 5 1.06 1.18 825,053

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 18 3.39 4.59 3,217,670
Sellers 15 -6.28 6.55 -4,588,352
Net -- -2.90 1.96 -1,370,682

Concentration

Value ($MM) % O/S Shares
Total Inst. 51.16 68.00 47,627,662
Top 10 Inst. 45.47 60.65 42,476,814
Top 20 Inst. 49.99 66.33 46,457,278
Top 50 Inst. 51.15 67.99 47,622,314

Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.69 0.96 671,481
Aggressive Growth 1 0.61 0.84 589,825
Core Growth 4 0.08 0.12 81,656
Income 1 0.03 0.04 26,226
Income Value 1 0.03 0.04 26,226
Index 6 2.66 3.69 2,584,502
Other 26 31.35 42.56 29,806,433
Broker Dealer 5 0.03 0.04 25,141
GARP 3 0.12 0.21 147,025
Hedge Fund 14 19.17 26.57 18,607,687
Sector Specific 1 0.26 0.36 250,000
VC/Private Equi 3 11.78 15.39 10,776,580
Value 5 0.09 0.12 87,039
Core Value 3 0.07 0.10 68,363
Deep Value 2 0.02 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 50 61.76 43,256,219 -1,551,642
Europe 2 5.00 3,500,093 250,093

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,936,000 9.90 124,000 3/31/18
venBio Select Advisor LLC 6,241,581 8.91 -- 3/31/18
Stonepine Capital Management, LLC 6,180,033 8.82 2,620,134 3/31/18
Deerfield Management Company, L.P. 6,052,935 8.64 -- 3/31/18
Scale Management, LLC 3,852,134 5.50 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.18 -- 4/27/18
HBM Partners AG 3,500,000 5.00 250,000 12/31/17
Palo Alto Investors LP 3,013,793 4.30 -- 3/31/18
The Vanguard Group, Inc. 2,100,182 3.00 30,462 3/31/18
Acuta Capital Partners, LLC 974,318 1.39 -- 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,374,781 1.96 -- 5/31/18
Vanguard Extended Market Index Fund 517,627 0.74 -- 5/31/18
Bridgeway Ultra-Small Company Market Fund 460,000 0.66 -- 3/31/18
iShares Micro-Cap ETF 157,263 0.22 49,691 6/30/18
Vanguard Institutional Total Stock Market Index Fund 132,811 0.19 -- 5/31/18
VALIC Co I Small Cap Fund 115,025 0.16 -- 5/31/18
Fidelity Extended Market Index Fund 102,415 0.15 -- 5/31/18
iShares Core S&P Total U.S. Stock Market ETF 92,490 0.13 7,120 6/30/18
Worldwide Healthcare Trust PLC 62,500 0.09 -- 3/31/18
Vanguard Balanced Index Fund 26,500 0.04 -18,100 5/31/18

* Insider values reflect direct beneficial ownership.

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