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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 66 66.10 71.44 46,365,616
Mutual Fund 22 3.84 4.02 2,609,575
Insider 6 0.82 1.07 697,473

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 19 10.49 12.69 8,234,882
Sellers 36 -17.55 19.57 -12,700,287
Net -- -7.06 6.88 -4,465,405

Concentration

Value ($MM) % O/S Shares
Total Inst. 66.10 71.44 46,365,616
Top 10 Inst. 54.15 58.41 37,908,850
Top 20 Inst. 63.73 68.87 44,697,275
Top 50 Inst. 66.07 71.41 46,345,425

Style

Holders Value ($MM) % Inst Shares Shares
Growth 11 1.14 1.25 812,865
Aggressive Growth 1 0.87 0.96 624,269
Core Growth 10 0.27 0.29 188,596
Income 1 0.04 0.04 26,226
Income Value 1 0.04 0.04 26,226
Index 5 3.19 3.51 2,275,116
Other 26 46.62 49.80 32,323,598
Broker Dealer 4 0.82 0.91 587,805
GARP 6 0.78 0.83 536,023
Hedge Fund 10 21.37 23.52 15,263,231
Sector Specific 1 0.35 0.39 250,000
VC/Private Equi 5 23.30 24.17 15,686,539
Value 6 0.12 0.14 89,028
Core Value 4 0.10 0.11 70,352
Deep Value 2 0.03 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 55 65.24 42,342,931 -1,427,777
Europe 2 5.01 3,250,093 3,250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Deerfield Management Company, L.P. 5,878,015 9.06 -- 3/31/17
venBio Select Advisor LLC 5,791,581 8.92 1,757,093 3/31/17
Armistice Capital LLC 4,436,000 6.83 1,236,000 3/31/17
Scale Management, LLC 3,977,391 6.13 -- 4/25/17
Domain Associates, L.L.C. 3,625,838 5.59 -- 4/25/17
HBM Partners AG 3,250,000 5.01 3,250,000 12/31/16
Polaris Venture Partners 3,148,355 4.85 -- 9/30/16
Palo Alto Investors, LLC 3,013,793 4.64 -- 3/31/17
Stonepine Capital Management, LLC 2,576,273 3.97 -2,039,540 3/31/17
Sofinnova Ventures, Inc. 2,211,604 3.41 -75,614 5/10/16

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 889,093 1.37 -- 4/30/17
Vanguard Extended Market Index Fund 734,725 1.13 162,842 3/31/17
Bridgeway Ultra-Small Company Market Fund 234,444 0.36 -- 12/31/16
Vanguard Institutional Total Stock Market Index Fund 132,811 0.20 -- 4/30/17
VALIC Co I Small Cap Fund 115,025 0.18 90,000 3/31/17
iShares Micro-Cap ETF 104,389 0.16 -2,690 5/31/17
Fidelity Extended Market Index Fund 102,415 0.16 -- 4/30/17
iShares Core S&P Total U.S. Stock Market ETF 63,350 0.10 4,200 5/31/17
Worldwide Healthcare Trust PLC 62,500 0.10 -- 2/28/17
Vanguard Balanced Index Fund 44,600 0.07 -- 4/30/17

* Insider values reflect direct beneficial ownership.

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