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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 64 62.14 63.34 43,736,240
Mutual Fund 20 3.48 3.62 2,499,537
Insider 6 0.82 1.01 697,473

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 17 6.31 7.62 5,259,272
Sellers 22 -12.15 12.53 -8,648,828
Net -- -5.85 4.91 -3,389,556

Concentration

Value ($MM) % O/S Shares
Total Inst. 62.14 63.34 43,736,240
Top 10 Inst. 53.21 54.15 37,389,375
Top 20 Inst. 59.80 60.93 42,071,739
Top 50 Inst. 62.11 63.31 43,713,541

Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 0.86 0.89 616,815
Aggressive Growth 1 0.54 0.56 389,825
Core Growth 9 0.32 0.33 226,990
Income 1 0.04 0.04 26,226
Income Value 1 0.04 0.04 26,226
Index 6 2.85 2.96 2,046,598
Other 28 46.68 47.13 32,543,552
Broker Dealer 4 0.51 0.53 366,768
GARP 4 0.25 0.25 173,950
Hedge Fund 14 22.19 23.12 15,966,295
Sector Specific 1 0.35 0.36 250,000
VC/Private Equi 5 23.38 22.86 15,786,539
Value 5 0.12 0.13 89,016
Core Value 3 0.10 0.10 70,340
Deep Value 2 0.03 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 53 57.51 39,713,555 -6,266,399
Europe 2 4.71 3,250,093 3,250,093

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 5,900,000 8.54 1,464,000 6/30/17
venBio Select Advisor LLC 5,891,581 8.53 100,000 6/30/17
Deerfield Management Company, L.P. 4,769,551 6.91 -1,108,464 6/30/17
Scale Management, LLC 3,977,391 5.76 -- 4/25/17
Domain Associates, L.L.C. 3,625,838 5.25 -- 4/25/17
HBM Partners AG 3,250,000 4.71 3,250,000 12/31/16
Polaris Venture Partners 3,148,355 4.56 -- 9/30/16
Palo Alto Investors, LLC 3,013,793 4.36 -- 6/30/17
Sofinnova Ventures, Inc. 2,211,604 3.20 -75,614 5/10/16
The Vanguard Group, Inc. 1,601,262 2.32 -230,330 6/30/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,006,674 1.46 100,351 8/31/17
Vanguard Extended Market Index Fund 487,165 0.71 -- 8/31/17
Bridgeway Ultra-Small Company Market Fund 260,000 0.38 -234,444 6/30/17
Vanguard Institutional Total Stock Market Index Fund 132,811 0.19 -- 8/31/17
VALIC Co I Small Cap Fund 115,025 0.17 -- 5/31/17
Fidelity Extended Market Index Fund 102,415 0.15 -- 8/31/17
iShares Micro-Cap ETF 98,068 0.14 -5,995 9/30/17
iShares Core S&P Total U.S. Stock Market ETF 77,290 0.11 7,980 9/30/17
Worldwide Healthcare Trust PLC 62,500 0.09 -- 6/30/17
Vanguard Balanced Index Fund 44,600 0.06 -- 8/31/17

* Insider values reflect direct beneficial ownership.

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