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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 70 62.66 82.26 53,353,666
Mutual Fund 22 3.46 3.88 2,519,906
Insider 6 0.82 1.08 697,473

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 22 7.39 10.51 6,814,777
Sellers 28 -4.17 5.83 -3,784,327
Net -- 3.22 4.68 3,030,450

Concentration

Value ($MM) % O/S Shares
Total Inst. 62.66 82.26 53,353,666
Top 10 Inst. 46.64 61.33 39,779,173
Top 20 Inst. 60.08 78.98 51,226,197
Top 50 Inst. 62.60 82.17 53,299,411

Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 0.50 0.71 460,685
Aggressive Growth 1 0.30 0.42 274,269
Core Growth 9 0.21 0.29 186,416
Income 1 0.04 0.04 26,226
Income Value 1 0.04 0.04 26,226
Index 5 2.14 3.05 1,979,012
Other 32 44.73 58.01 37,628,841
Broker Dealer 4 0.92 1.31 848,301
GARP 6 0.18 0.17 113,194
Hedge Fund 16 20.28 28.55 18,519,581
Sector Specific 1 0.27 0.39 250,000
VC/Private Equi 5 23.08 27.59 17,897,765
Value 5 0.11 0.14 88,603
Core Value 3 0.09 0.11 69,927
Deep Value 2 0.02 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 59 75.62 49,050,639 902,850
Europe 2 5.01 3,250,093 3,250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Deerfield Management Company, L.P. 5,878,015 9.06 -- 12/31/16
Intersouth Partners 4,877,480 7.52 -- 10/13/16
Stonepine Capital Management, LLC 4,615,813 7.12 2,708,623 12/31/16
venBio Select Advisor LLC 4,034,488 6.22 459,488 12/31/16
Scale Management, LLC 3,977,391 6.13 4,174 10/13/16
Domain Associates, L.L.C. 3,625,838 5.59 -- 10/13/16
Armistice Capital LLC 3,358,000 5.18 158,000 1/9/17
HBM Partners AG 3,250,000 5.01 3,250,000 12/31/16
Polaris Venture Partners 3,148,355 4.85 -- 9/30/16
Palo Alto Investors, LLC 3,013,793 4.65 -- 12/31/16

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 889,093 1.37 123,160 3/31/17
Vanguard Extended Market Index Fund 734,725 1.13 162,842 3/31/17
Bridgeway Ultra-Small Company Market Fund 234,444 0.36 -- 12/31/16
Vanguard Institutional Total Stock Market Index Fund 132,811 0.20 2,511 3/31/17
iShares Micro-Cap ETF 107,079 0.17 -- 3/31/17
Fidelity Extended Market Index Fund 102,415 0.16 -- 3/31/17
Worldwide Healthcare Trust PLC 62,500 0.10 -- 12/31/16
iShares Core S&P Total U.S. Stock Market ETF 61,470 0.09 2,320 4/30/17
Vanguard Balanced Index Fund 44,600 0.07 -- 3/31/17
Fidelity NASDAQ Composite Index Fund 32,140 0.05 -- 3/31/17

* Insider values reflect direct beneficial ownership.

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