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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 62 59.88 72.73 50,938,938
Mutual Fund 17 3.40 4.42 3,095,511
Insider 5 1.06 1.18 825,053

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 18 3.39 4.59 3,217,670
Sellers 18 -6.47 6.72 -4,705,746
Net -- -3.08 2.13 -1,488,076

Concentration

Value ($MM) % O/S Shares
Total Inst. 59.88 72.73 50,938,938
Top 10 Inst. 52.95 63.93 44,776,108
Top 20 Inst. 58.43 70.78 49,569,802
Top 50 Inst. 59.87 72.72 50,931,827

Style

Holders Value ($MM) % Inst Shares Shares
Growth 6 0.69 0.96 671,581
Aggressive Growth 1 0.61 0.84 589,825
Core Growth 5 0.08 0.12 81,756
Income 1 0.03 0.04 26,226
Income Value 1 0.03 0.04 26,226
Index 6 2.66 3.69 2,584,502
Other 27 37.82 47.07 32,966,025
Broker Dealer 5 0.04 0.05 36,378
GARP 3 0.15 0.21 147,025
Hedge Fund 14 19.17 26.57 18,607,687
Sector Specific 1 0.26 0.36 250,000
VC/Private Equi 4 18.21 19.88 13,924,935
Value 5 0.09 0.12 87,039
Core Value 3 0.07 0.10 68,363
Deep Value 2 0.02 0.03 18,676

Location: Global Region

Holders % O/S Shares Share Change
North America 51 66.43 46,529,831 -1,428,391
Europe 2 5.00 3,500,093 250,093

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 6,936,000 9.90 124,000 3/31/18
venBio Select Advisor LLC 6,241,581 8.91 -- 3/31/18
Stonepine Capital Management, LLC 6,180,033 8.82 2,620,134 3/31/18
Deerfield Management Company, L.P. 6,052,935 8.64 -- 3/31/18
Scale Management, LLC 3,977,391 5.68 -- 4/25/17
Domain Associates, L.L.C. 3,625,838 5.18 -- 4/25/17
HBM Partners AG 3,500,000 5.00 250,000 12/31/17
Polaris Venture Partners 3,148,355 4.50 -- 9/30/16
Palo Alto Investors, LLC 3,013,793 4.30 -- 3/31/18
The Vanguard Group, Inc. 2,100,182 3.00 30,462 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,374,781 1.96 -- 4/30/18
Vanguard Extended Market Index Fund 517,627 0.74 -- 4/30/18
Bridgeway Ultra-Small Company Market Fund 460,000 0.66 -- 3/31/18
Vanguard Institutional Total Stock Market Index Fund 132,811 0.19 -- 4/30/18
VALIC Co I Small Cap Fund 115,025 0.16 -- 3/31/18
iShares Micro-Cap ETF 111,100 0.16 3,528 4/30/18
Fidelity Extended Market Index Fund 102,415 0.15 -- 3/31/18
iShares Core S&P Total U.S. Stock Market ETF 86,770 0.12 1,400 4/30/18
Worldwide Healthcare Trust PLC 62,500 0.09 -- 1/31/18
Vanguard Balanced Index Fund 44,600 0.06 -- 4/30/18

* Insider values reflect direct beneficial ownership.

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