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Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 57 50.91 70.21 49,170,712
Mutual Fund 17 3.14 4.35 3,047,262
Insider 5 1.06 1.18 825,053

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 14 2.47 3.47 2,432,988
Sellers 26 -6.48 6.86 -4,806,163
Net -- -4.01 3.39 -2,373,175

Concentration

Value ($MM) % O/S Shares
Total Inst. 50.91 70.21 49,170,712
Top 10 Inst. 44.77 61.99 43,417,474
Top 20 Inst. 49.73 68.56 48,016,379
Top 50 Inst. 50.91 70.20 49,169,457

Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.48 0.70 491,481
Aggressive Growth 1 0.48 0.70 489,825
Core Growth 4 -- -- 1,656
Income 2 0.03 0.04 27,642
Income Value 1 0.03 0.04 26,226
Yield 1 -- -- 1,416
Index 6 2.56 3.73 2,614,247
Other 23 30.96 43.83 30,699,768
Broker Dealer 4 1.14 1.67 1,166,568
GARP 3 0.15 0.21 146,925
Hedge Fund 12 17.96 26.21 18,359,695
Sector Specific 1 0.24 0.36 250,000
VC/Private Equi 3 11.46 15.39 10,776,580
Value 4 0.08 0.11 77,082
Core Value 2 0.05 0.08 54,890
Deep Value 2 0.02 0.03 22,192

Location: Global Region

Holders % O/S Shares Share Change
North America 46 63.96 44,799,269 -2,401,458
Europe 2 5.00 3,500,093 250,000

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Stonepine Capital Management, LLC 6,981,184 9.97 801,151 6/30/18
Armistice Capital LLC 6,936,000 9.90 -- 6/30/18
venBio Select Advisor LLC 6,241,581 8.91 -- 6/30/18
Deerfield Management Company, L.P. 6,052,935 8.64 -- 6/30/18
Scale Management, LLC 3,852,134 5.50 -125,257 4/27/18
Domain Associates, L.L.C. 3,625,838 5.18 -- 4/27/18
HBM Partners AG 3,500,000 5.00 250,000 12/31/17
Palo Alto Investors LP 3,013,793 4.30 -- 6/30/18
The Vanguard Group, Inc. 2,082,082 2.97 -18,100 6/30/18
Morgan Stanley & Co. LLC 1,131,927 1.62 1,131,927 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,374,781 1.96 -- 8/31/18
Vanguard Extended Market Index Fund 518,727 0.74 1,100 8/31/18
Bridgeway Ultra-Small Company Market Fund 360,000 0.51 -100,000 6/30/18
iShares Micro-Cap ETF 164,373 0.23 7,110 8/31/18
Vanguard Institutional Total Stock Market Index Fund 132,811 0.19 -- 8/31/18
VALIC Co I Small Cap Fund 115,025 0.16 -- 7/31/18
Fidelity Extended Market Index Fund 102,415 0.15 -- 7/31/18
iShares Core S&P Total U.S. Stock Market ETF 94,290 0.13 1,800 8/31/18
Worldwide Healthcare Trust PLC 62,500 0.09 -- 5/31/18
Vanguard Balanced Index Fund 34,640 0.05 8,140 8/31/18

* Insider values reflect direct beneficial ownership.

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